The standardization of nursing diagnoses and interventions has been promoted as a strategy to strengthen the discipline and professional practice. However, these systems have been developed predominantly from hegemonic epistemologies of the Global North, resulting in limited appropriation in diverse sociocultural contexts. From the perspectives of the Epistemologies of the Global South and decolonial theory, this reflective work analyzes the importance of constructing nursing diagnoses and interventions that are contextualized and situated, responding to the historical, cultural, and social realities of each country. It argues that the lack of contextual congruence has contributed to their limited use and acceptance in daily practice, and that a decolonial perspective can foster the production of legitimate, relevant, and emancipatory knowledge for nursing.