There will be no force greater than Artificial Intelligence (AI) impacting on Nursing Informatics in the next five years. Other areas of impact are predictive analytics for predicting risks of patients in multiple condition and disease categories. In addition, the following areas will be impacting on nursing informatics: computerized decision support, natural language processing, robotics, virtual nursing, remote monitoring and telehealth. Each of these forces impacting nursing informatics will be discussed in this keynote.